A peer-reviewed Matters Arising correspondence published in Alzheimer’s Research & Therapy discusses methodological considerations in how digital cognitive assessments are compared across studies and datasets.

The publication examines considerations related to cross-study performance comparisons and the use of contemporaneous, comparable datasets when interpreting relative findings among digital cognitive assessment tools.

The correspondence also summarizes multiple peer-reviewed findings from the Bio-Hermes study supporting Cognivue Clarity^®’s:

• Psychometric validity
• Biomarker associations
• Generalizability across diverse populations
• Ability to characterize amyloid status and preclinical Alzheimer’s disease
• Amyloid risk prediction through the Cognivue Amyloid Risk Measure (CARM)*

The publication further discusses the importance of transparent and harmonized evaluation approaches in digital cognitive assessment research and clinical interpretation.

Cognivue remains committed to rigorous scientific validation, evidence-based research, and advancing scalable approaches for cognitive assessment and early detection.

Read the published correspondence here: https://link.springer.com/article/10.1186/s13195-026-02057-w

*patent pending